Please use this identifier to cite or link to this item: https://hdl.handle.net/20.500.12530/87812
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dc.contributor.authorFernandez-Cotarelo, Maria-Jose-
dc.contributor.authorGuerra-Vales, Juan Manuel-
dc.contributor.authorColina, Francisco-
dc.contributor.authorde la Cruz, Javier-
dc.date.accessioned2024-02-08T17:09:54Z-
dc.date.available2024-02-08T17:09:54Z-
dc.date.issued2010-01-31-
dc.identifier.citationTumori.2010;(96)1:111-6es_ES
dc.identifier.issn0300-8916-
dc.identifier.urihttps://hdl.handle.net/20.500.12530/87812-
dc.description.abstractAims and background. Patients with cancer of an unknown primary site (CUP) usually have a poor outcome. The identification of prognostic factors that affect survival can help clinicians find a better approach to such cases in terms of diagnostic and therapeutic management. Methods. We conducted a retrospective study including the cases of CUP recorded at the University Hospital 12 de Octubre Tumor Registry between 1999 and 2003. Results. CUP was diagnosed in 265 patients during the analyzed period. One hundred and seventy-one were men (64.5%) and the mean age of the patients was 66.9 years (range 32-98 years). The median survival was 2.5 months, and the survival rate was 35.1% 6 months from diagnosis (95% CI: 28.9-41.3) and 24.5% 1 year from diagnosis (95% CI: 18.7-30.3). Univariate analysis revealed as significant predictive variables of a better outcome age under 70 years; involvement of a single organ; normal serum levels of alkaline phosphatase and albumin; normal erythrocyte sedimentation rate; normal levels of the serum tumor markers CEA, CA 19.9 and CA 15.3; squamous carcinoma histology; clinical presentation as lymph node enlargement; and the administration of treatment. Multivariate analysis showed that albumin and alkaline phosphatase levels, squamous carcinoma histology, age and treatment were the most important prognostic factors. Other variables analyzed (liver, bone or lung involvement, lactate dehydrogenase levels, gender) did not affect survival. Conclusions. CUP has a poor prognosis. Some prognostic factors that affect survival in these patients, however, may be identified.es_ES
dc.language.isoenes_ES
dc.publisherSAGE Publicationses_ES
dc.relation.isversionofPostprintes_ES
dc.rightsinfo:eu-repo/semantics/openAccesses_ES
dc.rights.urihttp://creativecommons.org/licenses/by-nc-nd/3.0/es/*
dc.subjectTumor metastasises_ES
dc.subjectUnknown primary tumorses_ES
dc.subjectSurvivales_ES
dc.subjectPrognosises_ES
dc.subject.meshAdultes_ES
dc.subject.meshAge Factorses_ES
dc.subject.meshAgedes_ES
dc.subject.meshAged, 80 and overes_ES
dc.subject.meshAlkaline Phosphatasees_ES
dc.subject.meshBiomarkers, Tumores_ES
dc.subject.meshCarcinoma, Squamous Celles_ES
dc.subject.meshFemalees_ES
dc.subject.meshHumanses_ES
dc.subject.meshKaplan-Meier Estimatees_ES
dc.subject.meshMalees_ES
dc.subject.meshMiddle Agedes_ES
dc.subject.meshMultivariate Analysises_ES
dc.subject.meshNeoplasms, Unknown Primaryes_ES
dc.subject.meshPredictive Value of Testses_ES
dc.subject.meshPrognosises_ES
dc.subject.meshRetrospective Studieses_ES
dc.subject.meshRisk Assessmentes_ES
dc.subject.meshRisk Factorses_ES
dc.subject.meshSerum Albumines_ES
dc.titlePrognostic factors in cancer of unknown primary sitees_ES
dc.typeArtículoes_ES
dc.identifier.pubmedID20437867es_ES
dc.format.volume96es_ES
dc.format.page111es_ES
dc.description.peerreviewedes_ES
dc.relation.publisherversionhttps://journals.sagepub.com/doi/10.1177/030089161009600118?url_ver=Z39.88-2003&rfr_id=ori:rid:crossref.org&rfr_dat=cr_pub%20%200pubmedes_ES
dc.identifier.journalTumories_ES
dc.identifier.journalabbreviationTumories_ES
dc.contributor.authoraffiliationHospital Universitario de Mostoleses_ES
dc.format.number1es_ES
Appears in Collections:Hospitales > H. U. de Móstoles > Artículos

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